GENERAL TOXICITY AND IMMUNOTOXICITY OF ANTITUMOR AGENTS
نویسندگان
چکیده
منابع مشابه
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Different acid chlorides (2a-d) reacted with anthranilic acid to produce 2-substituted-3, 1-benzoxazin-4-one (3a-d) which was used as starting material to synthesize some condensed and non-condensed heterocyclic compounds by reaction with nitrogen nucleophiles e.g., hydrazine hydrate, and formamide. Some of the newly synthesized analogues were chosen to evaluate their cytotoxic activity against...
متن کاملSynthesis, Biological Evaluation and Docking Analysis of Some Novel Quinazolin Derivatives as Antitumor Agents
Different acid chlorides (2a-d) reacted with anthranilic acid to produce 2-substituted-3, 1-benzoxazin-4-one (3a-d) which was used as starting material to synthesize some condensed and non-condensed heterocyclic compounds by reaction with nitrogen nucleophiles e.g., hydrazine hydrate, and formamide. Some of the newly synthesized analogues were chosen to evaluate their cytotoxic activity against...
متن کاملStructure-activity studies of methylnitrosourea antitumor agents with reduced murine bone marrow toxicity.
Structure-activity studies were performed to compare the biological and chemical activities of five methylnitrosoureas, including four compounds with substitution of the 1methyl-1-nitrosoureido group onto the carbon-1 or carbon2 position of glucose or galactose. Following equimolar i.p. injections to mice of doses that were lethal in 10% of them, all four sugar-containing analogs were found to ...
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ژورنال
عنوان ژورنال: The Journal of Toxicological Sciences
سال: 1991
ISSN: 0388-1350,1880-3989
DOI: 10.2131/jts.16.supplementii_21